Skip to main content

Evidence-Based Supplement Research

Evidence-Based Supplement Research

Polypodium Leucotomos and Reduced UVA-Induced Thymidine Dimer Level

Doses used in studies

mg/day: 480 (median 480, IQR 480–480) — 1 study

Time to effect

Median: 4.3 weeks · IQR 4.3 weeks–4.3 weeks · Range 4.3 weeks–4.3 weeks — Reported in 1 of 1 study

1 of 1 paper

Changes in ultraviolet a radiation-induced thymidine dimers and erythema after oral nicotinamide or polypodium leucotomos extract in healthy volunteers: a randomized intraindividual trial.
- 2026-03-16
- RCT
- Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 25(5)
- - Aheen Faisal
  - C M Lerche
  - T Douki
  - P A Philipsen
  - C Pihl
  - T Gregersen
  - J R Granborg
  - P Bjerring
  - M Haedersdal
  - S R Wiegell
- PubMed: 41838346
- DOI: 10.1007/s43630-026-00884-2
3 Insights on
- Reduced UVA-Induced Thymidine Dimer Level
- High evidence
- Adults
Neither treatment reduced UVA-induced TT-dimers in ... urine (NAM: p = 0.89; PL: p = 0.30).
Effect
Neutral
Effect size
Small
Significant
No
Dose
480 mg daily (Heliocare Advanced)