Effect of a polyphenol-rich pomegranate extract on plasma trimethylamine N-oxide levels following an oral carnitine challenge: a randomized controlled crossover trial in healthy adults.
- 2026-05-20
- Clinical Trial · n = 34
- Frontiers in nutrition 13
- Julia E Haarhuis
- Jennifer Ahn-Jarvis
- George M Savva
- Priscilla E Day-Walsh
- Clare Ferns
- Sarah Hughes
- Silas Triller
- Olla Al-Jaibaji
- Mark Philo
- Emrah Acaroz
- Natalia Perez-Moral
- Paul A Kroon
- PubMed: 42293209
- DOI: 10.3389/fnut.2026.1822840
- High evidence
- Adults
Pomegranate extract did not reduce TMAO AUC in the full Phase II cohort (placebo/pomegranate ratio 0.993, 95% CI 0.81-1.22; P = 0.945; n = 16).
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 1.6 g