Gastric cooling and menthol cause an increase in cardiac parasympathetic efferent activity in healthy adult human volunteers.
- 2018-08-19
- RCT
- Experimental physiology 103(10)
- Lubobo-Claude Kazadi
- Janine Fletcher
- Paul A Barrow
- PubMed: 30070742
- DOI: 10.1113/ep087058
- High evidence
- Adults
Gastric stretch only caused a significant reduction in QTc interval lasting up to 15 min, with a concomitant but non-significant increase in heart rate, indicating an increased sympathetic cardiac tone.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 300 ml of solution at 37°C