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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Pygeum and Improved Maximum Urinary Flow Rate

Doses used in studies

mg/day: 100–1,000 (median 550, IQR 325–775) — 2 studies

Time to effect

Median: 7.1 months · IQR 4.5 months–9.6 months · Range 8.6 weeks–12.2 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
The safety profile was similar between groups and study phases.
from: Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients wi
Overall tolerabilityReported
No treatment-related adverse effects were observed.
from: Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benig

2 of 2 papers

Comparison of once and twice daily dosage forms of Pygeum africanum extract in patients with benign prostatic hyperplasia: a randomized, double-blind study, with long-term open label extension.
- 1999-09-01
- RCT
- Urology 54(3)
- - C Chatelain
  - W Autet
  - F Brackman
- PubMed: 10475357
- DOI: 10.1016/s0090-4295(99)00147-8
3 Insights on
- Improved Maximum Urinary Flow Rate
- High evidence
- Clinical
Qmax increased by 2.02 mL/s (19%) in group B
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
100 mg once daily
Efficacy and acceptability of tadenan (Pygeum africanum extract) in the treatment of benign prostatic hyperplasia (BPH): a multicentre trial in central Europe.
- 1998-01-01
- Clinical Trial · n = 85
- Current medical research and opinion 14(3)
- - J Breza
  - O Dzurny
  - A Borowka
  - T Hanus
  - R Petrik
  - G Blane
  - H Chadha-Boreham
- PubMed: 9787978
- DOI: 10.1185/03007999809113352
10 Insights on
- Improved Maximum Urinary Flow Rate
- High evidence
- Clinical
Mean maximum urinary flow, average urinary flow and urine volume were also statistically significantly improved
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
50 mg twice daily