Resveratrol and Reduced Systolic Blood Pressure

Research synthesisModerate evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects on systolic blood pressure, with effect sizes ranging from small to moderate. The evidence is primarily from clinical populations with type 2 diabetes or coronary artery disease, though one study (a single-dose acute trial) was neutral.

Studied populations: clinical populations with type 2 diabetes or coronary artery disease

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One study tested resveratrol combined with beetroot extract, which may confound results. No consistent dose or form data were reported across studies, and the neutral study was an acute intervention, limiting comparability with longer-term supplementation trials.

Generated Jul 16, 2026

Doses used in studies

mg/day: 500 (median 500, IQR 500–500) — 1 study

3 of 3 papers

Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.
- 2025-01-24
- RCT
- European journal of nutrition 64(2)
- - Luana Almeida Gonzaga
  - Andrey Alves Porto
  - Carolina Takahashi
  - Rayana Loch Gomes
  - Luiz Carlos Marques Vanderlei
  - Vitor Engrácia Valenti
- PubMed: 39853480
- DOI: 10.1007/s00394-025-03582-4
3 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Rigorous Journal
- Clinical
For SBP, significantly higher values concerning rest were observed at the first minute of recovery for all protocols.
Effect
Neutral
Effect size
Small
Significant
No
Dose
500 mg
Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.
- 2025-05-29
- Systematic Review · n = 337
- Phytotherapy research : PTR 39(12)
- - Runyu Miao
  - Boxun Zhang
  - Danni Zhou
  - Mengjiao Kang
  - Jiaxing Tian
  - Linhua Zhao
  - Xiaolin Tong
- PubMed: 40439602
- DOI: 10.1002/ptr.8431
12 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
Resveratrol significantly improved … systolic blood pressure (SBP) … (P < 0.05)
Effect
Beneficial
Effect size
Small
Significant
Yes
Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.
- 2026-04-15
- Meta-Analysis
- Nutrition journal 25(1)
- - Jia-Nan Sun
  - Rui Yang
  - Li Fang
  - Yun-Jia Li
  - Wei-Yi Xing
  - Ming-Li Sun
  - Lang Wu
  - Qi-Jun Wu
  - Ting-Ting Gong
- PubMed: 41987155
- DOI: 10.1186/s12937-026-01319-5
11 Insights on
- Reduced Systolic Blood Pressure
- High evidence
- Clinical
systolic blood pressure (MD = -7.97 mmHg, 95% CI = -10.63, -5.31) among patients with type 2 diabetes
Effect
Beneficial
Effect size
Moderate
Significant
Yes

Resveratrol and Reduced Systolic Blood Pressure

Acute effects of beetroot extract and resveratrol ingestion on cardiovascular and cardiac autonomic modulation recovery after moderate-intensity aerobic exercise in individuals with coronary artery disease: a triple-blinded, randomized, placebo-controlled trial.

Clinical Efficacy of Curcumin, Resveratrol, Silymarin, and Berberine on Cardio-Metabolic Risk Factors Among Patients With Type 2 Diabetes Mellitus: A Systemic Review and Bayesian Network Meta-Analysis.

Effects of resveratrol supplementation on multiple health outcomes: an umbrella review of systematic reviews and meta-analyses of randomized controlled trials.