Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study.
- 2025-12
- RCT
- The American journal of clinical nutrition 122(6)
- Camille Amadieu
- Quentin Leyrolle
- Milena Farneti
- Andrea Anesi
- Eva Bruchet
- Juliette Montet
- Sandra Dexpert
- David Gaudout
- Fulvio Mattivi
- Line Pourtau
- Nathalie Castanon
- Lucile Capuron
- PubMed: 41047129
- DOI: 10.1016/j.ajcnut.2025.09.050
- High evidence
- Clinical
it improved autoperceived mental health, as reflected in increased mental health scores over time on the Medical Outcome Study Short-Form 12 questionnaire, compared with placebo (mean at 6 wk: 53.8 ± 12.7 vs 44.6 ± 11.4 for placebo and saffron group, respectively; time × treatment, P = 0.04).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes