Saffron and Reduced Composite Depression, Anxiety, and Fatigue Score

• Effect of saffron extract supplementation on mood in healthy adults with subclinical symptoms of depression: a randomized, double-blind placebo-controlled study.

  • 2025-12
  • RCT
  • The American journal of clinical nutrition 122(6)
  • • Camille Amadieu
    • Quentin Leyrolle
    • Milena Farneti
    • Andrea Anesi
    • Eva Bruchet
    • Juliette Montet
    • Sandra Dexpert
    • David Gaudout
    • Fulvio Mattivi
    • Line Pourtau
    • Nathalie Castanon
    • Lucile Capuron

  • PubMed: 41047129
  • DOI: 10.1016/j.ajcnut.2025.09.050

  7 Insights on

  • Reduced Composite Depression, Anxiety, and Fatigue Score

  • High evidence
  • Clinical

  Saffron extract did not significantly affect the primary outcome of combined depressive, anxiety, and fatigue symptoms (z-score)

  Effect

  Neutral

  Effect size

  Small

  Significant

  No