Saw Palmetto and Reduced Total Prostate-Specific Antigen Level

Doses used in studies

mg/day: 320 (median 320, IQR 320–320) — 2 studies

Time to effect

Median: 3.2 months · IQR 8.3 weeks–4.4 months · Range 3 weeks–5.6 months — Reported in 2 of 2 studies

Safety in these studies

Overall tolerabilityReported
The Serenoa repens extract was effective, safe, well-tolerated, and clinically and statistically superior to placebo in the target LUTS/BPH population.
from: Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperpl
adverse eventsReported2 (1.18%) of 169 patients in the placebo group and 3 (1.89) of 159 patients in the Serenoa repens extract group experienced 1 or more adverse events
Two (1.18%) of 169 patients in the placebo group and 3 (1.89) of 159 patients in the Serenoa repens extract group experienced 1 or more adverse events.
from: Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperpl

2 of 2 papers

Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.
- 2019-03-14
- RCT · n = 354
- Urology 129
- - Zhangqun Ye
  - Jian Huang
  - Liqun Zhou
  - Shan Chen
  - Zengjun Wang
  - Lulin Ma
  - Dongfang Wang
  - Gongxian Wang
  - Shusheng Wang
  - Chaozhao Liang
  - Shaopeng Qiu
  - Xiaojian Gu
  - Jianhe Liu
  - Zhiliang Weng
  - Changli Wu
  - Qiang Wei
  - Liping Xie
  - Weizhen Wu
  - Yue Cheng
  - Jingqian Hu
  - Zhixian Wang
  - Xiaoyong Zeng
- PubMed: 30880074
- DOI: 10.1016/j.urology.2019.02.030
10 Insights on
- Reduced Total Prostate-Specific Antigen Level
- High evidence
- Large Human Trial
- Clinical
Secondary efficacy parameters included improvement of ... and total prostate-specific antigen level.
Effect
Neutral
Effect size
Small
Significant
No
Dose
320 mg
Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®).
- 2014-07-19
- RCT · n = 210
- BMC urology 14
- - Gian Maria Busetto
  - Riccardo Giovannone
  - Matteo Ferro
  - Stefano Tricarico
  - Francesco Del Giudice
  - Deliu Victor Matei
  - Ottavio De Cobelli
  - Vincenzo Gentile
  - Ettore De Berardinis
- PubMed: 25038794
- DOI: 10.1186/1471-2490-14-53
6 Insights on
- Reduced Total Prostate-Specific Antigen Level
- High evidence
- Large Human Trial
- Clinical
A statistically significant difference was found at the time of the follow-up between Group A and B in the NIH-CPSI questionnaire score, symptoms evidence and serum PSA.
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
320 mg

Saw Palmetto and Reduced Total Prostate-Specific Antigen Level

Efficacy and Safety of Serenoa repens Extract Among Patients with Benign Prostatic Hyperplasia in China: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial.

Chronic bacterial prostatitis: efficacy of short-lasting antibiotic therapy with prulifloxacin (Unidrox®) in association with saw palmetto extract, lactobacillus sporogens and arbutin (Lactorepens®).