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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Senna and Improved Bowel Cleansing Quality

Doses used in studies

mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Safety in these studies

abdominal painIncreased risk70.9% vs 43%
abdominal pain rates were 70.9% and 43%, respectively
from: Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative pros
nauseaIncreased risk28.7% vs 43.9%
nausea rates were 28.7% and 43.9%
from: Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative pros
vomitingIncreased risk12.7% vs 29.5%
The rates of vomiting in the senna and PEG groups were 12.7% and 29.5%
from: Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative pros

1 of 1 paper

Polyethylene glycol versus split high-dose senna for bowel preparation: A comparative prospective randomized study.
- 2020-06-08
- RCT · n = 237
- Journal of gastroenterology and hepatology 35(11)
- - Yusuf Coskun
  - Ilhami Yuksel
- PubMed: 32424868
- DOI: 10.1111/jgh.15101
3 Insights on
- Improved Bowel Cleansing Quality
- High evidence
- Large Human Trial
The quality of colon cleansing and the ease of bowel preparation were significantly better in the senna group; the mean of total BBPS scores was 7.35 in the senna group and 6.57 in the PEG group, cleansing was adequate (BBPS score ≥ 6) in 89.9% of patients taking senna, and 73.8% in the PEG group (P = 0.001).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
1000 mg split high-dose