Sesame and Reduced Phlebitis Incidence

• Effect of sesame oil and Nigella sativa oil on the prevention of amiodarone-induced phlebitis: a randomized controlled trial.

  • 2026-03-18
  • RCT · n = 108
  • Explore (New York, N.Y.) 22(3)
  • • Burcu Nal
    • Dilek Sari
    • Mehmet Ali Astarcioğlu
    • İsmail Şen

  • PubMed: 41880716
  • DOI: 10.1016/j.explore.2026.103403

  2 Insights on

  • Reduced Phlebitis Incidence

  • High evidence
  • Large Human Trial
  • Clinical

  Phlebitis was observed in 25% of patients in the sesame oil group, 33.3% in the Nigella sativa oil group, and 80.6% in the control group.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes

  Dose

  five drops topically to a 10-cm area around the catheter site every 6 hours

• Effects of open-label sesame oil applied to cardiac surgery patients in preventing amiodarone-induced phlebitis: A randomized controlled trial.

  • 2024-04-27
  • RCT · n = 44
  • Nursing in critical care 30(2)
  • • Muaz Gülşen
    • Sevban Arslan

  • PubMed: 38676381
  • DOI: 10.1111/nicc.13085

  2 Insights on

  • Reduced Phlebitis Incidence

  • High evidence
  • Clinical

  The incidence of phlebitis was 20/22 (90.9%) in the intervention group and 22/22 (100%) in the control group. There was no statistically significant difference in phlebitis symptoms between groups.

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  10 drops applied to a 10 cm perimeter of the cannula for 10 minutes, repeated every 8 hours during 24-hour amiodarone infusion