Effect of sesame oil and Nigella sativa oil on the prevention of amiodarone-induced phlebitis: a randomized controlled trial.
- 2026-03-18
- RCT · n = 108
- Explore (New York, N.Y.) 22(3)
- Burcu Nal
- Dilek Sari
- Mehmet Ali Astarcioğlu
- İsmail Şen
- PubMed: 41880716
- DOI: 10.1016/j.explore.2026.103403
- High evidence
- Large Human Trial
- Clinical
A significant difference in phlebitis severity was observed between the groups (p < 0.001), with the highest severity in the control group, the lowest in the sesame oil group, and moderate levels in the Nigella sativa oil group.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- five drops topically to a 10-cm area around the catheter site every 6 hours