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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Turmeric and Increased Brain-derived Neurotrophic Factor Level

Doses used in studies

g/day: 2 (median 2, IQR 2–2) — 1 study
mg/day: 1,330 (median 1,330, IQR 1,330–1,330) — 1 study

Time to effect

Median: 7 weeks · IQR 6.5 weeks–7.5 weeks · Range 6 weeks–8 weeks — Reported in 2 of 2 studies

2 of 2 papersPopulation:

A Randomized Controlled Trial to Determine the Effects of Curcumin and Epigallocatechin-3-Gallate Supplementation on Serum Brain-Derived Neurotrophic Factor and Mood Disturbance in Adults.
- 2026-03-06
- RCT
- Nutrients 18(5)
- - Aidan M Cavanah
  - Laura A Robinson
  - Madison M Aguilar
  - Elaine F Molaison
  - Michael W Greene
  - Michael D Roberts
  - Andrew D Fruge
- PubMed: 41830024
- DOI: 10.3390/nu18050855
8 Insights on
- Increased Brain-derived Neurotrophic Factor Level
- High evidence
- Rigorous Journal
- Adults
Mean serum BDNF increased in both groups, but neither were statistically significant with no group-by-time interactions.
Effect
Neutral
Effect size
Small
Significant
No
Dose
1330 mg/day
Does curcumin supplementation affect inflammation, blood count and serum brain-derived neurotropic factor concentration in amateur long-distance runners?
- 2025-01-14
- RCT · n = 15
- PloS one 20(1)
- - Sebastian Bańkowski
  - Ziemowit Bronisław Wójcik
  - Małgorzata Grabara
  - Dariusz Ozner
  - Tomasz Pałka
  - Agata Stanek
  - Ewa Sadowska-Krępa
- PubMed: 39808679
- DOI: 10.1371/journal.pone.0317446
6 Insights on
- Increased Brain-derived Neurotrophic Factor Level
- High evidence
- Athletes
These findings do not support a significant effect of curcumin supplementation on ... BDNF concentration.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2g/day