Turmeric and Reduced Matrix Metalloproteinase-3 Level

• Effect of Curcuma longa extract on serum inflammatory markers and MRI-based synovitis in knee osteoarthritis: secondary analyses from the CurKOA randomised trial.

  • 2023-01
  • RCT · n = 36
  • Phytomedicine : international journal of phytotherapy and phytopharmacology 109
  • • Zhiqiang Wang
    • Tania Winzenberg
    • Ambrish Singh
    • Dawn Aitken
    • Leigh Blizzard
    • Mikael Boesen
    • Edwin H G Oei
    • Tijmen A van Zadelhoff
    • Venkat Parameswaran
    • Changhai Ding
    • Robert Jones
    • Benny Antony

  • PubMed: 36610110
  • DOI: 10.1016/j.phymed.2022.154616

  5 Insights on

  • Reduced Matrix Metalloproteinase-3 Level

  • High evidence
  • Clinical

  MMP-3 levels decreased in both CL (-1.31 ng/ml [95%CI: -1.89 to -0.73]) and placebo (-2.34 ng/ml [95%CI: -2.95 to -1.73]) groups, with the placebo group having a slightly greater decrease (1.03 ng/ml [95%CI: 0.19 to 1.88]).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No