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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Turmeric and Reduced Tumor Necrosis Factor Alpha

Doses used in studies

mg/day: 200–500 (median 325, IQR 225–450) — 2 studies
g/day: 2 (median 2, IQR 2–2) — 1 study

Time to effect

Median: 9.4 weeks · IQR 7.7 weeks–11.1 weeks · Range 6 weeks–3 months — Reported in 2 of 2 studies

2 of 2 papersPopulation:

Efficacy and safety evaluation of Boswellia serrata and Curcuma longa extract combination in the management of chronic lower back pain: A randomised, double-blind, placebo-controlled clinical study.
- 2024-12-18
- RCT · n = 45
- Explore (New York, N.Y.) 21(1)
- - Anuradha Majumdar
  - Mungara Anjaneya Venkata Vara Prasad
  - Satish Reddy Gandavarapu
  - Kalakata Sudhir Kumar Reddy
  - Varun Sureja
  - Dharmeshkumar Kheni
  - Vishal Dubey
- PubMed: 39700654
- DOI: 10.1016/j.explore.2024.103099
9 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Clinical
This group demonstrated a significant reduction in inflammatory biomarker levels (tumour necrosis factor-α...)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
300 mg CL20192 once daily
Does curcumin supplementation affect inflammation, blood count and serum brain-derived neurotropic factor concentration in amateur long-distance runners?
- 2025-01-14
- RCT · n = 15
- PloS one 20(1)
- - Sebastian Bańkowski
  - Ziemowit Bronisław Wójcik
  - Małgorzata Grabara
  - Dariusz Ozner
  - Tomasz Pałka
  - Agata Stanek
  - Ewa Sadowska-Krępa
- PubMed: 39808679
- DOI: 10.1371/journal.pone.0317446
6 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Athletes
The results showed no significant changes in ... tumor necrosis factor α (TNF-α)... due to curcumin supplementation.
Effect
Neutral
Effect size
Small
Significant
No
Dose
2g/day