Vitex and Reduced Premenstrual Syndrome Symptom

• Vitex agnus-castus extracts for female reproductive disorders: a systematic review of clinical trials.

  • 2012-11-07
  • Systematic Review
  • Planta medica 79(7)
  • • M Diana van Die
    • Henry G Burger
    • Helena J Teede
    • Kerry M Bone

  • PubMed: 23136064
  • DOI: 10.1055/s-0032-1327831

  7 Insights on

  • Reduced Premenstrual Syndrome Symptom

  • High evidence
  • Clinical

  For premenstrual syndrome, seven of eight trials found Vitex extracts to be superior to placebo (5 of 6 studies), pyridoxine (1), and magnesium oxide (1).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• Efficacy and safety of Vitex agnus-castus extract for treatment of premenstrual syndrome in Japanese patients: a prospective, open-label study.

  • 2014-03
  • Clinical Trial
  • Advances in therapy 31(3)
  • • Mikio Momoeda
    • Hidetaka Sasaki
    • Eiko Tagashira
    • Masayuki Ogishima
    • Yuichi Takano
    • Kazunori Ochiai

  • PubMed: 24604699
  • DOI: 10.1007/s12325-014-0106-z

  15 Insights on

  • Reduced Premenstrual Syndrome Symptom

  • Moderate evidence
  • Clinical

  After the first menstrual cycle, a statistically significant decrease in total VAS score was observed (P<0.001), and the score continued to diminish for the following two cycles.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

  Dose

  20 mg once daily