White Mulberry and Reduced Postprandial Glucose

Research synthesisModerate evidenceMixed effect size4 studies · 3 beneficial · 1 neutral · 0 harmful

Across 4 randomized controlled trials, 3 reported beneficial effects of white mulberry on reducing postprandial glucose, with effect sizes ranging from small to large. Doses varied widely (from 2.90 mg to 1.5 g per 100 g carbohydrate) and no consistent form was used. The evidence suggests a potential benefit, but the magnitude of effect is mixed across studies.

Caveats: Doses varied widely across studies, making it difficult to determine an optimal dose. One study in individuals with type 2 diabetes found no significant effect with a low-dose mulberry fruit extract (0.37 g), suggesting effectiveness may be dose-dependent. Most studies used mulberry fruit extract, but one used leaf extract; form may influence outcomes. Study durations were not consistently reported, limiting assessment of long-term effects.

Generated May 18, 2026

Doses used in studies

mg/day: 2.9–250 (median 126.45, IQR 64.68–188.23) — 2 studies
g single-dose: 0.37 (median 0.37, IQR 0.37–0.37) — 1 study

Safety in these studies

Overall tolerabilityReported
There were no indications of adverse events or gastrointestinal discomfort.
from: Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A

4 of 4 papersPopulation:

Bioequivalence of Mulberry Fruit Extract and 1-Deoxynojirimycin for Postprandial Blood Glucose Lowering: A Randomized Trial in Humans.
- 2025-07
- RCT · n = 84
- The Journal of nutrition 155(7)
- - Anne-Roos Hoogenraad
  - Marian Geldof
  - Harry Hiemstra
  - Arienne de Jong
  - Guus S Duchateau
  - David J Mela
- PubMed: 40419090
- DOI: 10.1016/j.tjnut.2025.05.037
2 Insights on
- Reduced Postprandial Glucose
- High evidence
- Adults
Although both MFE and DNJ produced absolute reductions in mean PPG and PPI relative to the control, these effects were more robust for MFE than DNJ.
Effect
Beneficial
Effect size
Small
Significant
Yes
Dose
2.90 mg
The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread.
- 2023-08-10
- RCT
- PloS one 18(8)
- - Fangli Ding
  - Qing Wang
  - Chen Xie
  - Meng Wang
  - Lu Zhang
  - Ming Gao
  - Zongling Yang
  - Jianrui Ma
  - Xiaodong Shi
  - Wei Chen
  - Shenglin Duan
  - Peng Yuan
  - Yali Li
  - Xishan Ma
  - Yimin Wu
  - Jia Liu
  - Xiaowen Feng
  - Qingli Cheng
  - Zichun Wang
  - Xuyan Li
  - Jingmei Huang
- PubMed: 37561734
- DOI: 10.1371/journal.pone.0288911
3 Insights on
- Reduced Postprandial Glucose
- High evidence
The addition of MLE significantly reduced the total blood glucose rise after ingestion of WB over 120 minutes, and reduced the GI value of WB in a dose-effect relationship. When the concentration of MLE reached 1.5 g per 100 g available carbohydrate, the GI value of WB could be reduced from 77 to 43.
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
three different levels; up to 1.5 g per 100 g available carbohydrate
Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Individuals with Type 2 Diabetes.
- 2024-07-09
- RCT
- Nutrients 16(14)
- - David J Mela
  - Marjan Alssema
  - Harry Hiemstra
  - Anne-Roos Hoogenraad
  - Tanvi Kadam
- PubMed: 39064619
- DOI: 10.3390/nu16142177
2 Insights on
- Reduced Postprandial Glucose
- High evidence
- Rigorous Journal
- Clinical
0.37 g of MFE reduced the mean 2 hr PPG by 8.2% (-20.8 to 6.6%)
Effect
Neutral
Effect size
Small
Significant
No
Dose
0.37 g added to ~50 g available carbohydrates from rice
Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies.
- 2022-06-28
- RCT
- Nutrients 14(13)
- - Nele Gheldof
  - Celia Francey
  - Andreas Rytz
  - Léonie Egli
  - Frederik Delodder
  - Lionel Bovetto
  - Nathalie Piccardi
  - Christian Darimont
- PubMed: 35807854
- DOI: 10.3390/nu14132674
1 Insight on
- Reduced Postprandial Glucose
- High evidence
- Rigorous Journal
rather than ingested 5 min before (−26%, p = 0.002)
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Dose
250 mg

White Mulberry and Reduced Postprandial Glucose

Bioequivalence of Mulberry Fruit Extract and 1-Deoxynojirimycin for Postprandial Blood Glucose Lowering: A Randomized Trial in Humans.

The impact of mulberry leaf extract at three different levels on reducing the glycemic index of white bread.

Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Individuals with Type 2 Diabetes.

Effect of Different Nutritional Supplements on Glucose Response of Complete Meals in Two Crossover Studies.