Research synthesisModerate evidenceSmall effect5 studies · 4 beneficial · 1 neutral · 0 harmful
Across 5 studies, 4 reported beneficial effects of white mulberry on reducing postprandial glucose, with effect sizes ranging from small to moderate. The predominant effect size is small-to-moderate, and the evidence includes multiple RCTs, though one smaller trial in people with type 2 diabetes showed a non-significant neutral effect. Doses varied widely (e.g., 250 mg to ~1.5 g per serving), and most studies involved single-meal acute challenges rather than long-term supplementation.
- Effective dose range: 250 mg to ~1.5 g per serving (as mulberry fruit or leaf extract, administered with a carbohydrate-containing meal)
- Studied populations: healthy adults, people with type 2 diabetes (limited evidence)
Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies are acute postprandial challenges rather than long-term interventions; effects on sustained glycemic control are less established. One small pilot trial in type 2 diabetes showed a non-significant neutral effect, suggesting potential variability in response depending on population and dose.
Generated Jun 12, 2026