Calcium and Increased Adverse Effect

• Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

  • 2025-12-03
  • Meta-Analysis · n = 9,430
  • The Cochrane database of systematic reviews 2026(1)
  • • Catherine A Cluver
    • Christa Rohwer
    • Anke C Rohwer

  • PubMed: 41330480
  • DOI: 10.1002/14651858.cd001059.pub6

  8 Insights on

  • Increased Adverse Effect

  • High evidence
  • Pregnant Women

  The evidence is very uncertain about the effect of calcium on ... adverse effects (RR 2.16, 95% CI 0.43 to 10.78; 2 RCTs, 714 women; very low-certainty evidence).

  Effect

  Harmful

  Effect size

  Small

  Significant

  No

  Dose

  varied across trials