Calcium and Reduced Perinatal Loss

• Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

  • 2025-12-03
  • Meta-Analysis · n = 9,430
  • The Cochrane database of systematic reviews 2026(1)
  • • Catherine A Cluver
    • Christa Rohwer
    • Anke C Rohwer

  • PubMed: 41330480
  • DOI: 10.1002/14651858.cd001059.pub6

  8 Insights on

  • Reduced Perinatal Loss

  • High evidence
  • Pregnant Women

  calcium may result in little to no difference in perinatal loss (RR 0.93, 95% CI 0.64 to 1.35; 4 RCTs, 6832 women; RD 1/1000 fewer, 95% CI 6 fewer to 6 more; low-certainty evidence).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No

  Dose

  varied across trials