Calcium and Reduced Pre-eclampsia

• Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

  • 2025-12-03
  • Meta-Analysis · n = 9,430
  • The Cochrane database of systematic reviews 2026(1)
  • • Catherine A Cluver
    • Christa Rohwer
    • Anke C Rohwer

  • PubMed: 41330480
  • DOI: 10.1002/14651858.cd001059.pub6

  8 Insights on

  • Reduced Pre-eclampsia

  • High evidence
  • Pregnant Women

  Calcium may result in little to no difference in pre-eclampsia (risk ratio (RR) 0.83, 95% confidence interval (CI) 0.67 to 1.04; 6 RCTs, 15,364 women; risk difference (RD) 9/1000 fewer, 95% CI 17 fewer to 2 more; low-certainty evidence). Sensitivity analysis excluding small studies (fewer than 500 participants) indicates little to no difference in pre-eclampsia (RR 0.92, 95% CI 0.79 to 1.05; 4 RCTs, 14,730 women; high-certainty evidence).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No

  Dose

  varied across trials, not specified per group in abstract

• Calcium supplementation commenced before pregnancy for preventing hypertensive disorders and related problems.

  • 2025-09-18
  • Meta-Analysis · n = 1,355
  • The Cochrane database of systematic reviews 2025(9)
  • • Catherine A Cluver
    • Christa Rohwer
    • Anke Rohwer
    • Maria Eduarda Dos Santos Santos Puga
    • Maria Regina Torloni
    • G Justus Hofmeyr

  • PubMed: 40965861
  • DOI: 10.1002/14651858.cd011192.pub4

  7 Insights on

  • Reduced Pre-eclampsia

  • High evidence
  • Clinical

  Compared to placebo, calcium may result in little to no difference in pre-eclampsia (RR 0.84, 95% CI 0.62 to 1.14; 1 RCT, 1355 women; low-certainty evidence).

  Effect

  Neutral

  Effect size

  Small

  Significant

  No

  Dose

  Supplemented as calcium carbonate (1000 mg/day)