Calcium and Reduced Pre-eclampsia or Pregnancy Loss

Doses used in studies

Calcium Carbonate · mg/day: 1,000 (median 1,000, IQR 1,000–1,000) — 1 study

Safety in these studies

Overall tolerabilityNo significant differenceSerious adverse eventRR 0.97, 95% CI 0.70 to 1.35
The evidence is very uncertain about the effect of calcium, compared to placebo, on maternal death or severe morbidity (RR 0.97, 95% CI 0.70 to 1.35; 1 RCT, 1355 women; RD 3/1000 fewer, 95% CI 29 fewer to 34 more; very low-certainty evidence).
from: Calcium supplementation commenced before pregnancy for preventing hypertensive disorders a

1 of 1 paper

Calcium supplementation commenced before pregnancy for preventing hypertensive disorders and related problems.

2025-09-18
Meta-Analysis · n = 1,355
The Cochrane database of systematic reviews 2025(9)
- Catherine A Cluver
- Christa Rohwer
- Anke Rohwer
- Maria Eduarda Dos Santos Santos Puga
- Maria Regina Torloni
- G Justus Hofmeyr

PubMed: 40965861
DOI: 10.1002/14651858.cd011192.pub4

7 Insights on

Reduced Pre-eclampsia or Pregnancy Loss

High evidence
Clinical

Compared to placebo, calcium may result in little to no difference in pre-eclampsia or pregnancy loss at any gestational age (risk ratio (RR) 0.85, 95% CI 0.67 to 1.07; 1 RCT, 1355 women; low-certainty evidence).

Effect: Neutral
Effect size: Small
Significant: No
Dose: Supplemented as calcium carbonate (1000 mg/day)