Calcium and Reduced Preterm Delivery

• Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems.

  • 2025-12-03
  • Meta-Analysis · n = 9,430
  • The Cochrane database of systematic reviews 2026(1)
  • • Catherine A Cluver
    • Christa Rohwer
    • Anke C Rohwer

  • PubMed: 41330480
  • DOI: 10.1002/14651858.cd001059.pub6

  8 Insights on

  • Reduced Preterm Delivery

  • High evidence
  • Pregnant Women

  The evidence is very uncertain about the effect of calcium on preterm delivery before 37 weeks (RR 0.83, 95% CI 0.65 to 1.05; 6 RCTs, 15,074 women; very low-certainty evidence). Sensitivity analysis excluding small studies indicates little to no difference in preterm delivery before 37 weeks (RR 0.97, 95% CI 0.85 to 1.11; 4 RCTs, 14,429 women; high-certainty evidence).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  No

  Dose

  varied across trials