Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors.
- 2026-06-04
- Meta-Analysis · n = 7,475
- The Cochrane database of systematic reviews 2026(6)
- Louise J Geneen
- Karyna Atha
- Catherine Kimber
- William McClune
- Carolyn Dorée
- Chiara Vendramin
- Lian Wea Chia
- David J Roberts
- PubMed: 42240175
- DOI: 10.1002/14651858.cd009532.pub3
- High evidence
- Adults
The deferral rate due to low Hb (critical outcome) is probably reduced (risk ratio (RR) 0.39, 95% CI 0.20 to 0.76; 7 studies, 1647 participants; moderate-certainty evidence) with oral iron supplementation at the first donation since commencement of treatment when compared to no iron. This is a clinically important effect.
- Effect
- Beneficial
- Effect size
- Large
- Significant
- Yes
- Dose
- variable (7 to 105 mg/day elemental iron)