Iron and Reduced Transfusion Rate

• Comparative Efficacy of Perioperative Blood Conservation Agents in Pediatric Cranial Vault Remodeling: A Systematic Review and Network Meta-Analysis.

  • 2025-10-15
  • Meta-Analysis · n = 1,072
  • Neurosurgery 98(3)
  • • Christopher C Padilla
    • Michael Farid
    • Parker Smith
    • Kwadwo Darko
    • Kwadwo Darko
    • Sean O'Leary
    • Bennett Levy
    • Umaru Barrie
    • Hammad Khan
    • Salah G Aoun
    • David H Harter

  • PubMed: 41090904
  • DOI: 10.1227/neu.0000000000003798

  4 Insights on

  • Reduced Transfusion Rate

  • High evidence
  • Clinical

  Combination therapy with TXA + EPO + iron (OR: 0.004, 95% CI: 0.002-0.10) ... were associated with reductions in transfusion rates.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes