Magnesium and Reduced C-Reactive Protein Levels

Research synthesisLow evidenceSmall effect3 studies · 2 beneficial · 1 neutral · 0 harmful

Across 3 studies, 2 reported beneficial effects of magnesium on reducing C-reactive protein levels, while 1 found neutral results. The beneficial effects were typically small to moderate in magnitude, with statistically significant reductions observed in systematic reviews of participants with metabolic syndrome and overweight/obese populations. Effects were observed at a median study duration of approximately 12 weeks, though data on dose and form were insufficient for generalisation.

Studied populations: people with metabolic syndrome; overweight/obese individuals

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One neutral trial combined magnesium with L-carnitine in NAFLD patients, which may confound the isolated effect of magnesium. Two of the beneficial studies tested magnesium in combination with vitamin D, making it unclear whether magnesium alone is responsible. Dose and form data were missing for most studies, limiting practical recommendations.

Generated Jun 12, 2026

Doses used in studies

mg/day: 150 (median 150, IQR 150–150) — 1 study

Time to effect

Median: 2.9 months · IQR 10.4 weeks–3.3 months · Range 8.6 weeks–3.7 months — Reported in 2 of 3 studies

3 of 3 papers

The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.
- 2025-10-31
- Systematic Review · n = 444
- Frontiers in nutrition 12
- - Weinai Wang
  - Jiayong Wang
  - Yufeng Yang
  - Yan Shi
- PubMed: 41245414
- DOI: 10.3389/fnut.2025.1692937
1 Insight on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
Compared with placebo, magnesium intake notably lowered C-reactive protein (CRP) levels in serum (SMD = -0.327; 95% CI: -0.602 to -0.053; p = 0.048).
Effect
Beneficial
Effect size
Small
Significant
Yes
The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analysis.
- 2025-09-01
- Systematic Review · n = 509
- Frontiers in nutrition 12
- - Kai Deng
  - Jiamei Liu
  - Ye Miao
  - Guanqi Wang
  - Xingli Wang
  - Shengye Liu
  - Liyu Yang
- PubMed: 40959697
- DOI: 10.3389/fnut.2025.1563604
2 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
In subgroup analysis, serum levels of hs-CRP was notably reduced in individuals receiving magnesium and vitamin D supplementation (MD = -0.66, 95%CI: -1.17, -0.14, p = 0.01).
Effect
Beneficial
Effect size
Moderate
Significant
Yes
Hepatoprotective effect of combination of L-carnitine and magnesium-hydroxide in nonalcoholic fatty liver disease patients: a double-blinded randomized controlled pilot study.
- 2022-10-01
- RCT
- European review for medical and pharmacological sciences 26(20)
- - R Hazzan
  - N Abu Ahmad
  - W Slim
  - E Mazen
  - Z Neeman
- PubMed: 36314323
- DOI: 10.26355/eurrev_202210_30023
6 Insights on
- Reduced C-Reactive Protein Levels
- High evidence
- Clinical
serum CRP levels, insulin levels, lipid profile and LS were not affected by treatment.
Effect
Neutral
Effect size
Small
Significant
No
Dose
150 mg/day

Magnesium and Reduced C-Reactive Protein Levels

The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.

The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analysis.

Hepatoprotective effect of combination of L-carnitine and magnesium-hydroxide in nonalcoholic fatty liver disease patients: a double-blinded randomized controlled pilot study.