Magnesium and Reduced C-Reactive Protein Levels

• The effect of long-term magnesium intake on inflammatory markers in patients with metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials.

  • 2025-10-31
  • Systematic Review · n = 444
  • Frontiers in nutrition 12
  • • Weinai Wang
    • Jiayong Wang
    • Yufeng Yang
    • Yan Shi

  • PubMed: 41245414
  • DOI: 10.3389/fnut.2025.1692937

  1 Insight on

  • Reduced C-Reactive Protein Levels

  • High evidence
  • Clinical

  Compared with placebo, magnesium intake notably lowered C-reactive protein (CRP) levels in serum (SMD = -0.327; 95% CI: -0.602 to -0.053; p = 0.048).

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes

• The effects of magnesium and vitamin D/E co-supplementation on inflammation markers and lipid metabolism of obese/overweight population: a systematic review and meta-analysis.

  • 2025-09-01
  • Systematic Review · n = 509
  • Frontiers in nutrition 12
  • • Kai Deng
    • Jiamei Liu
    • Ye Miao
    • Guanqi Wang
    • Xingli Wang
    • Shengye Liu
    • Liyu Yang

  • PubMed: 40959697
  • DOI: 10.3389/fnut.2025.1563604

  2 Insights on

  • Reduced C-Reactive Protein Levels

  • High evidence
  • Clinical

  In subgroup analysis, serum levels of hs-CRP was notably reduced in individuals receiving magnesium and vitamin D supplementation (MD = -0.66, 95%CI: -1.17, -0.14, p = 0.01).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes