Research synthesisLow evidenceMixed effect size3 studies · 2 beneficial · 1 neutral · 0 harmful
Across 3 studies, 2 reported beneficial effects of magnesium on reducing C-reactive protein (CRP) levels, with effect sizes ranging from small to moderate, while 1 study found no effect. The beneficial effects were statistically significant in both supporting studies, which were systematic reviews of clinical populations (metabolic syndrome and overweight/obese individuals). Effects were typically observed at a median study duration of 86 days (~12 weeks), but the evidence base is small and preliminary.
- Studied populations: people with metabolic syndrome, overweight/obese population
Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. One of the beneficial studies examined magnesium co-administered with vitamin D, so the independent effect of magnesium is unclear. The neutral study used a specific form (magnesium hydroxide) and a low dose (150 mg/day), which may not reflect typical magnesium supplementation. Dose and form data were largely missing across studies, limiting dose-response conclusions.
Generated Jul 12, 2026