Selenium and Reduced Joint Tenderness

• Effect of selenium supplementation on inflammatory markers and joint symptoms in patients with rheumatoid arthritis: A meta-analysis and systematic review.

  • 2025-10
  • Meta-Analysis · n = 367
  • Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 91
  • • Manyu Long
    • Shaohong Xu
    • Songyuan Tie
    • Shuming Dong
    • Hui Liang
    • Jing Wang
    • Shuya Wang

  • PubMed: 40695138
  • DOI: 10.1016/j.jtemb.2025.127695

  2 Insights on

  • Reduced Joint Tenderness

  • High evidence
  • Clinical

  and the Ritchie index (MD = -1.13, 95 % CI [-2.22, - 0.05], P = 0.04)

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes