Selenium and zinc in acute kidney injury: A systematic scoping review of speciation-resolved mechanisms, analytical validation, and translational biomarkers.
- 2026-08
- Review · n = 453
- Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 96
- Sharad Visht
- Muhamed Aydin Abbas
- Omji Porwal
- Rozhan Arif Muhammed
- Neeraj Kumar Fuloria
- Zainab Yalman Othman
- Sama Naziyah Shaban
- Bimlesh Kumar
- Rupesh Dudhe
- Sachin Kumar Singh
- PubMed: 42418850
- DOI: 10.1016/j.jtemb.2026.127923
- High evidence
- Clinical
Low plasma Se (<70 µg/L; <0.89 µmol/L) and Zn (<60 µg/dL; <9.2 µmol/L) was associated with increased incidence, severity, and mortality of AKI in clinical cohorts (n = 453-11,238); however, these relationships may be confounded by inflammation, acute-phase redistribution, and disease severity.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No