Bacillus clausii SC-109 and Enhanced Resistance to Bacterial Infections

• Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection.

  • 2024-10-03
  • Microbiology spectrum 12(10)
  • • Xue-Yin Wang
    • Fan-Hua Meng
    • Ming-Yue Zhang
    • Fen-Xin Li
    • Yu-Xin Lei
    • Zhao-Guo Ma
    • Jia-Qi Li
    • Ya-Nan Lou
    • Yue-Feng Chu
    • Ke Ma
    • Shui-Xing Yu

  • PubMed: 39190634
  • DOI: 10.1128/spectrum.04025-23

  7 Insights on

  • Enhanced Resistance to Bacterial Infections

  • Low evidence
  • Animal Study

  L. garvieae-pretreated mice were less susceptible to C. perfringens infection compared with PBS-pretreated mice, which manifested as higher survival rates, lower pathogen loads, less weight loss, mild clinical symptoms and intestinal damage, and minor inflammation.

  Effect

  Beneficial

  Effect size

  Large