Bacillus clausii SC-109 and Reduced Infection Severity

• Nasal delivery of killed Bacillus subtilis spores protects against influenza, RSV and SARS-CoV-2.

  • 2025-04-02
  • Frontiers in immunology 16
  • • Rong Xu
    • Huynh A Hong
    • Shadia Khandaker
    • Murielle Baltazar
    • Noor Allehyani
    • Daan Beentjes
    • Tessa Prince
    • Yen-Linh Ho
    • Linh Hanh Nguyen
    • Daniel Hynes
    • William Love
    • Simon M Cutting
    • Aras Kadioglu

  • PubMed: 40242757
  • DOI: 10.3389/fimmu.2025.1501907

  3 Insights on

  • Reduced Infection Severity

  • Low evidence

  mice pre-treated with spores developed resistance to all three pathogens and, in each case, exhibited a significant improvement in both survival rate and disease severity.

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes