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Evidence-Based Supplement Research

Evidence-Based Supplement Research

Bacillus clausii and Reduced Tumor Necrosis Factor Alpha

Doses used in studies

CFU single-dose: 5 billion (median 5 billion, IQR 5 billion–5 billion) — 1 study

2 of 2 papersPopulation:

Efficient symptomatic treatment and viral load reduction for children with influenza virus infection by nasal-spraying Bacillus spore probiotics.
- 2023-09-08
- RCT
- Scientific reports 13(1)
- - Tu Thanh Tran
  - Thuy Thi Bich Phung
  - Dien Minh Tran
  - Huyen Thi Bui
  - Phuc Thanh Thi Nguyen
  - Tam Thi Vu
  - Nga Thi Phuong Ngo
  - Mai Thi Nguyen
  - Anh Hoa Nguyen
  - Anh Thi Van Nguyen
- PubMed: 37684332
- DOI: 10.1038/s41598-023-41763-5
7 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Rigorous Journal
- Children
levels of pro-inflammatory cytokines IL-8, TNF-α, and IL-6 in nasopharyngeal samples were reduced by 1.1, 3.7, and 53.9 folds
Effect
Beneficial
Effect size
Large
Significant
Yes
Dose
5 billion spores in 5 mL (nasal spray)
Efficacy of Bacillus clausii as an adjuvant therapy in pathological neonatal unconjugated hyperbilirubinemia in the Nile Delta region of Egypt: a randomized controlled trial.
- 2026-06-11
- RCT · n = 22
- Journal of tropical pediatrics 72(4)
- - Samah S M Hussein
  - Sahar M El-Haggar
  - Sahar K Hegazy
  - Mohamed A Rowisha
- PubMed: 42378553
- DOI: 10.1093/tropej/fmag047
7 Insights on
- Reduced Tumor Necrosis Factor Alpha
- High evidence
- Clinical
By the end of treatment, the probiotic group showed a significantly greater reduction in lipopolysaccharide and tumor necrosis factor-α levels compared with the control group.
Effect
Beneficial
Effect size
Small
Significant
Yes