Bacillus subtilis HU58 and Reduced Lactate Levels

• Engineered Bacillus subtilis as Oral Probiotics To Enhance Clearance of Blood Lactate.

  • 2024-12-31
  • ACS synthetic biology 14(1)
  • • Mengdi Yang
    • Noah Hutchinson
    • Ningyuan Ye
    • Hania Timek
    • Maria Jennings
    • Jianing Yin
    • Ming Guan
    • Zongqi Wang
    • Peiru Chen
    • Shaobo Yang
    • Justin D Crane
    • Ke Zhang
    • Xuesong He
    • Jiahe Li

  • PubMed: 39739838
  • DOI: 10.1021/acssynbio.4c00399

  1 Insight on

  • Reduced Lactate Levels

  • Low evidence
  • Animal Study

  oral administration of engineered B. subtilis spores to the gut of mice reduced the level of blood lactate in two different mouse models involving exogenous challenge or pharmacologic perturbation

  Effect

  Beneficial

  Effect size

  Moderate