Bacillus subtilis MB40 and Improved Immune Response

• The Probiotic Bacillus subtilis MB40 Improves Immunity in a Porcine Model of Listeriosis.

  • 2023-08-18
  • RCT
  • Microorganisms 11(8)
  • • Sean M Garvey
    • Nima K Emami
    • Justin L Guice
    • Nammalwar Sriranganathan
    • Christopher Penet
    • Robert P Rhoads
    • Jessica L Spears
    • Rami A Dalloul
    • Samer W El-Kadi

  • PubMed: 37630670
  • DOI: 10.3390/microorganisms11082110

  2 Insights on

  • Improved Immune Response

  • High evidence

  MB40 supplementation reduced LM bacterial counts in the liver and spleen by 67% (p < 0.001) and 49% (p < 0.001), respectively, following the LM challenge, compared to the basal diet. MB40 supplementation was also associated with decreased circulating concentrations of monocytes (p = 0.007). Altogether, these data suggest that MB40 supplementation is a safe and well-tolerated approach to enhance immunity during systemic Listeria infection.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes