Bacillus subtilis MB40 and Reduced Staphylococcus aureus Colonization

• Probiotic for pathogen-specific Staphylococcus aureus decolonisation in Thailand: a phase 2, double-blind, randomised, placebo-controlled trial.

  • 2023-02
  • RCT · n = 115
  • The Lancet. Microbe 4(2)
  • • Pipat Piewngam
    • Sunisa Khongthong
    • Natthrit Roekngam
    • Yongyuth Theapparat
    • Somkiat Sunpaweravong
    • Damrongsak Faroongsarng
    • Michael Otto

  • PubMed: 36646104
  • DOI: 10.1016/s2666-5247(22)00322-6

  2 Insights on

  • Reduced Staphylococcus aureus Colonization

  • High evidence
  • Large Human Trial

  Oral probiotic B subtilis resulted in significant reduction of S aureus in stool (96·8%; p<0·0001) and nose (65·4%; p=0·0002).

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes