Bifidobacterium animalis subsp. lactis BB-12 and Improved Defecation Condition

• Effect of the probiotic strain Bifidobacterium animalis subsp. lactis, BB-12®, on defecation frequency in healthy subjects with low defecation frequency and abdominal discomfort: a randomised, double-blind, placebo-controlled, parallel-group trial.

  • 2015-09-18
  • RCT · n = 1,248
  • The British journal of nutrition 114(10)
  • • Dorte Eskesen
    • Lillian Jespersen
    • Birgit Michelsen
    • Peter J Whorwell
    • Stefan Müller-Lissner
    • Cathrine M Morberg

  • PubMed: 26382580
  • DOI: 10.1017/s0007114515003347

  5 Insights on

  • Improved Defecation Condition

  • High evidence
  • Large Human Trial

  A treatment effect on average defecation frequency was found (P=0·0065), with the frequency being significantly higher compared with placebo at all weeks for probiotic treatment overall (all P<0·05)... Overall, 4 weeks' supplementation with the probiotic strain BB-12® resulted in a clinically relevant benefit on defecation frequency.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Understanding the probiotic health benefits of Bifidobacterium animalis subsp. lactis, BB-12™.

  • 2025-07-02
  • Review
  • Frontiers in microbiology 16
  • • Fergus W J Collins
    • Natalia I Vera-Jiménez
    • Anja Wellejus

  • PubMed: 40673154
  • DOI: 10.3389/fmicb.2025.1605044

  3 Insights on

  • Improved Defecation Condition

  • Low evidence

  BB-12 Bifidobacterium animalis subsp. lactis strain is one of the most documented probiotic strains on the market and has been shown to be effective in alleviating symptoms of a low defecation frequency

  Effect

  Beneficial

  Effect size

  Moderate