Bifidobacterium animalis subsp. lactis BB-12 and Increased Cytokine Secretion

• Probiotic Yogurt Culture Bifidobacterium Animalis Subsp. Lactis BB-12 and Lactobacillus Acidophilus LA-5 Modulate the Cytokine Secretion by Peripheral Blood Mononuclear Cells from Patients with Ulcerative Colitis.

  • 2016-02-24
  • Drug research 66(06)
  • • A Sheikhi
    • M Shakerian
    • H Giti
    • M Baghaeifar
    • A Jafarzadeh
    • V Ghaed
    • M R Heibor
    • N Baharifar
    • Z Dadafarin
    • G Bashirpour

  • PubMed: 26909690
  • DOI: 10.1055/s-0035-1569414

  1 Insight on

  • Increased Cytokine Secretion

  • Low evidence

  Both bacteria significantly augmented IL-10, TGF-β, IFN-γ and TNF-α compared to control (p<0.001). The secretion levels of IL-10 and TGF-β by B. lactis- compared to L. acidophilus-stimulated PBMCs were significantly higher (p<0.05, p<0.01 respectively). The secretion levels of TNF-α and IFN-γ by PBMCs after 72 h were significantly lower compared to 48 h stimulation by B. lactis (p<0.001, p<0.035 respectively).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes