Bifidobacterium animalis subsp. lactis BB-12 and Reduced Cariogenic Oral Microbiota

• Streptococcus dentisani as an oral probiotic: a systematic review of clinical evidence on the pH modulation and microbiota shifts.

  • 2025-12-21
  • Review
  • Journal of oral microbiology 18(1)
  • • Martín Pérez-Leal
    • Matteo Nakhle
    • Cristina Estornut
    • Germán Sánchez-Herrera
    • Pilar Ribera
    • Inés Roger
    • Nicla Flacco

  • PubMed: 41477312
  • DOI: 10.1080/20002297.2025.2605796

  5 Insights on

  • Reduced Cariogenic Oral Microbiota

  • Low evidence

  Two clinical studies specifically assessed S. dentisani, reporting transient oral colonization, increased salivary alkalinity, and reductions in S. mutans, with one trial documenting a favorable community shift by 16S sequencing.

  Effect

  Beneficial

  Effect size

  Small