Bifidobacterium animalis subsp. lactis BB-12 and Reduced Immune Protection

• Insufficient immune protection in preterm infants due to delayed or incomplete hexavalent vaccination.

  • 2025-10-21
  • Observational · n = 82
  • Frontiers in immunology 16
  • • Elisabeth Kaiser
    • Regine Weber
    • Michelle Bous
    • Ingmar Fortmann
    • Marie-Theres Dammann
    • Janina Marißen
    • Dorothee Viemann
    • Christoph Derouet
    • Steve Hein
    • Nasenien Nourkami-Tutdibi
    • Erol Tutdibi
    • Mara Wuhrmann
    • Muriel Charlotte Hans
    • Christian Gille
    • Stephan Gehring
    • Philipp Henneke
    • Christoph Härtel
    • Sybelle Goedicke-Fritz
    • Michael Zemlin

  • PubMed: 41194926
  • DOI: 10.3389/fimmu.2025.1626057

  2 Insights on

  • Reduced Immune Protection

  • Moderate evidence

  Due to insufficient adherence to vaccination recommendations, 42% of highly vulnerable preterm neonates were insufficiently protected against one or more vaccine-preventable diseases after one year.

  Effect

  Harmful

  Effect size

  Large