Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial
- 2018-02-08
- RCT · n = 228
- Gut Microbes 9(3)
- A. Ibarra
- Mathilde Latreille-Barbier
- Y. Donazzolo
- X. Pelletier
- A. Ouwehand
- PubMed: 29227175
- DOI: 10.1080/19490976.2017.1412908
- High evidence
- Rigorous Journal
- Clinical
There were no statistically significant differences in the primary or secondary outcomes between interventions.
- Effect
- Neutral
- Effect size
- Small
- Significant
- No
- Dose
- 1 × 10^9 or 1 × 10^10 CFU/day