Bifidobacterium animalis subsp. lactis HN019 and Increased Bowel Movements

• Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial

  • 2018-02-08
  • RCT · n = 228
  • Gut Microbes 9(3)
  • • A. Ibarra
    • Mathilde Latreille-Barbier
    • Y. Donazzolo
    • X. Pelletier
    • A. Ouwehand

  • PubMed: 29227175
  • DOI: 10.1080/19490976.2017.1412908

  22 Insights on

  • Increased Bowel Movements

  • High evidence
  • Rigorous Journal
  • Clinical

  A post hoc analysis of 65 participants with fewer than 3 bowel movements per week (BMF ≤ 3/week) showed a physiologically relevant increase in weekly BMF in the high- (+2.0) and low-dose (+1.7) HN019 groups—by RMANOVA, the HN019 groups with BMF ≤ 3/week, pooled together, had a higher BMF versus placebo (P value = 0.01).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

  Dose

  1 × 10^9 or 1 × 10^10 CFU/day