Bifidobacterium animalis subsp. lactis and Reduced Pancreatic Stress-Related Pathways

• Role of Bifidobacterium animalis subsp. lactis BB-12 in mice with acute pancreatitis.

  • 2025-04-05
  • AMB Express 15(1)
  • • Bingbing Du
    • Ren Yan
    • Xiaoxiang Hu
    • Jing Lou
    • Yixin Zhu
    • Yini Shao
    • Huiyong Jiang
    • Yingying Hao
    • Longxian Lv

  • PubMed: 40186645
  • DOI: 10.1186/s13568-025-01867-9

  5 Insights on

  • Reduced Pancreatic Stress-Related Pathways

  • Low evidence

  BB-12 mitigated the AP-induced dysregulation of several pathways, specifically attenuating the upregulation of the pancreatic secretion and ascorbate and aldarate metabolism pathways while reversing the downregulation of the ribosome, oxidative phosphorylation, and thermogenesis pathways.

  Effect

  Beneficial

  Effect size

  Small