Bifidobacterium animalis and Reduced Osteoclast Activity

• Bifidobacterium animalis RH exopolysaccharide bidirectionally modulates inflammatory bone metabolism disorders.

  • 2026-03
  • International journal of biological macromolecules 349
  • • Shuyuan Shi
    • Zeqian Yang
    • Zixin Han
    • Boqing Yao
    • Pinglan Li
    • Nan Shang

  • PubMed: 41672177
  • DOI: 10.1016/j.ijbiomac.2026.150784

  3 Insights on

  • Reduced Osteoclast Activity

  • Low evidence
  • Animal Study

  EPS attenuated osteoclastogenesis by reducing inflammatory cytokines (IL-6, IL-1β, TNF-α), inhibiting ROS generation, downregulating RANK expression

  Effect

  Beneficial

  Effect size

  Moderate