Bifidobacterium bifidum G9-1 and Improved Constipation Symptoms

• Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).

  • 2026-01-08
  • Clinical Trial · n = 30
  • Journal of diabetes investigation 17(3)
  • • Fuki Ikeda
    • Junko Sato
    • Hidenori Yoshii
    • Masahiro Sugawara
    • Hiroaki Satoh
    • Yukiko Sugawara
    • Hirotsugu Uzawa
    • Daisuke Sugimoto
    • Reina Muto
    • Yuya Nishida
    • Hirotaka Watada

  • PubMed: 41504339
  • DOI: 10.1111/jdi.70236

  6 Insights on

  • Improved Constipation Symptoms

  • High evidence

  The total constipation, abdominal pain, and indigestion scores on the Gastrointestinal Symptom Rating Scale significantly decreased. Abdominal symptoms, including straining, feelings of incomplete evacuation, bloating, and discomfort, significantly decreased.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes