Effects of probiotic Bifidobacterium bifidum G9‐1 on the gastrointestinal symptoms of patients with type 2 diabetes mellitus treated with metformin: An open‐label, single‐arm, exploratory research trial
- 2021-11-15
- Journal of Diabetes Investigation 13(3)
- Shinnosuke Hata
- Hanako Nakajima
- Y. Hashimoto
- Tomoki Miyoshi
- Yukako Hosomi
- Takuro Okamura
- Saori Majima
- Naoko Nakanishi
- Takafumi Sennmaru
- T. Osaka
- Hiroshi Okada
- Emi Ushigome
- M. Hamaguchi
- M. Asano
- M. Yamazaki
- M. Fukui
- PubMed: 34665938
- DOI: 10.1111/jdi.13698
- Low evidence
- Rigorous Journal
The gastrointestinal symptom rating scale total score significantly improved (from 2.02 ± 0.51 to 1.59 ± 0.43, change, -0.43 ± 0.49, P < 0.001).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes