Bifidobacterium bifidum G9-1 and Improved Stool Formation

• Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).

  • 2026-01-08
  • Clinical Trial · n = 30
  • Journal of diabetes investigation 17(3)
  • • Fuki Ikeda
    • Junko Sato
    • Hidenori Yoshii
    • Masahiro Sugawara
    • Hiroaki Satoh
    • Yukiko Sugawara
    • Hirotsugu Uzawa
    • Daisuke Sugimoto
    • Reina Muto
    • Yuya Nishida
    • Hirotaka Watada

  • PubMed: 41504339
  • DOI: 10.1111/jdi.70236

  6 Insights on

  • Improved Stool Formation

  • High evidence

  The proportion of patients with normal stool form at week 12 (44.8%; 13 patients) was significantly higher than that at baseline (3.3%; 1 patient; P = 0.002). The median Bristol score significantly increased from baseline by 0.6 at week 6 (P < 0.001) and 0.5 at week 12 (P < 0.001).

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes