Bifidobacterium bifidum G9-1 Intake Improves Gastrointestinal Symptoms in Type 2 Diabetes Mellitus: An Open-Label, Randomized Controlled Trial (Binary STAR Study).
- 2026-04-22
- RCT · n = 100
- Diabetes, obesity & metabolism 28(7)
- Genki Kobayashi
- Yoshitaka Hashimoto
- Tomoyuki Matsuyama
- Noriyuki Kitagawa
- Saori Majima
- Takafumi Senmaru
- Emi Ushigome
- Hiroshi Okada
- Naoko Nakanishi
- Masahide Hamaguchi
- Michiaki Fukui
- PubMed: 42017290
- DOI: 10.1111/dom.70805
- High evidence
- Large Human Trial
- Clinical
Among the GSRS subscales, BBG9-1 showed a significantly greater mean reduction in constipation scores than control (-0.79 ± 1.38 vs. -0.13 ± 1.04; p = 0.013).
- Effect
- Beneficial
- Effect size
- Small
- Significant
- Yes
- Dose
- 12 mg/day