Bifidobacterium bifidum G9-1 and Reduced Straining

• Efficacy of probiotics (Bifidobacterium bifidum G9-1) in patients with type 2 diabetes mellitus and chronic kidney disease complicated by constipation: An exploratory, multicenter, open-label, single-arm study (BIRDIE study).

  • 2026-01-08
  • Clinical Trial · n = 30
  • Journal of diabetes investigation 17(3)
  • • Fuki Ikeda
    • Junko Sato
    • Hidenori Yoshii
    • Masahiro Sugawara
    • Hiroaki Satoh
    • Yukiko Sugawara
    • Hirotsugu Uzawa
    • Daisuke Sugimoto
    • Reina Muto
    • Yuya Nishida
    • Hirotaka Watada

  • PubMed: 41504339
  • DOI: 10.1111/jdi.70236

  14 Insights on

  • Reduced Straining

  • High evidence

  Abdominal symptoms, including straining, feelings of incomplete evacuation, bloating, and discomfort, significantly decreased.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes

• Efficacy of Bifidobacterium bifidum G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study

  • 2024-04-02
  • Bioscience of Microbiota, Food and Health 40(2)
  • • A. Fuyuki
    • T. Higurashi
    • Takaomi Kessoku
    • K. Ashikari
    • Tsutomu Yoshihara
    • Noboru Misawa
    • Michihiro Iwaki
    • Takashi Kobayashi
    • H. Ohkubo
    • M. Yoneda
    • Haruki Usuda
    • K. Wada
    • A. Nakajima

  • PubMed: 33996367
  • DOI: 10.12938/bmfh.2020-073

  8 Insights on

  • Reduced Straining

  • Low evidence
  • Rigorous Journal

  Subset analysis revealed that patients with initial Bristol Stool Form Scale stool types of <4 had improvements in stool consistency, a significant increase in the frequency of bowel movements, and a significant alleviation in the degree of straining, following BBG9-1 administration.

  Effect

  Beneficial

  Effect size

  Moderate

  Significant

  Yes