The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients.
- 2025-08-25
- RCT · n = 369
- NPJ biofilms and microbiomes 11(1)
- Lin Zhang
- Shilan Wang
- Martin C S Wong
- Chris K P Mok
- Jessica Y L Ching
- Joyce W Y Mak
- Chunke Chen
- Bing Huo
- Shuai Yan
- Chun Pan Cheung
- Emily O L Chiu
- Emily Y T Fung
- Pui Kuan Cheong
- Francis K L Chan
- Siew C Ng
- PubMed: 40851072
- DOI: 10.1038/s41522-025-00804-9
- High evidence
- Large Human Trial
The enrichment of three bifidobacterial species after 3 months of SIM01 intervention (BABBBL_fc) was positively correlated with the level of neutralizing antibodies to the BNT162b2 vaccine at 6-month postvaccination.
- Effect
- Beneficial
- Effect size
- Moderate