An 8-Week Administration of Bifidobacterium bifidum and Lactobacillus plantarum Combined with Exercise Training Alleviates Neurotoxicity of Aβ and Spatial Learning via Acetylcholine in Alzheimer Rat Model
- 2021-03-14
- RCT · n = 25
- Journal of Molecular Neuroscience 71(7)
- Samaneh Shamsipour
- G. Sharifi
- F. Taghian
- PubMed: 33715084
- DOI: 10.1007/s12031-021-01812-y
- Low evidence
- Rigorous Journal
- Animal Study
- Clinical
Crystal violet analysis showed that sole (p < 0.01) and combined exercise training and probiotic supplementation (p < 0.001) significantly reduced the number of dead cells in the brains of rats compared with the AD group.
- Effect
- Beneficial
- Effect size
- Moderate
- Significant
- Yes