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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Bifidobacterium bifidum Rosell-71 and Improved Cognitive Function

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects on cognitive function, with effect sizes ranging from small to large (mixed). One meta-analysis found a statistically significant large effect (p=0.01, SMD −0.90) in patients with depression, but the other two reviews were not significant. The evidence base is small and preliminary, with no consistent dose or duration data.

  • Studied populations: patients with depressive symptoms and cognitive impairment, individuals with Alzheimer's disease, and general healthy adults

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Many of the included studies did not reach statistical significance — effect may be smaller than the predominant direction suggests. The one significant meta-analysis also reported high heterogeneity (I²=82%), indicating variability across included trials.

Generated Jul 12, 2026
3 of 3 papers
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