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Evidence-Based Supplement Research
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Bifidobacterium bifidum Rosell-71 and Improved Cognitive Function

Research synthesisVery low evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of Bifidobacterium bifidum Rosell-71 on cognitive function, with effect sizes ranging from small to large. The most robust evidence comes from a 2025 meta-analysis showing a large, statistically significant effect (p = 0.01; SMD, -0.90; 95% CI, -1.59 to -0.21) in patients with depression, but the evidence base is small and limited by the lack of dose and duration reporting.

  • Studied populations: adults with depression (from the meta-analysis), general adult humans (from reviews)

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Only one study (the meta-analysis) reported a statistically significant finding; the other two reviews did not provide significance data. Doses, study durations, and forms were not reported in any of the studies, limiting practical applicability.

Generated Jun 11, 2026
3 of 3 papers
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