Bifidobacterium bifidum UABb-10 and Improved Gut Barrier Function

• AG1®, a Novel Synbiotic, Maintains Gut Barrier Function following Inflammatory Challenge in a Caco-2/THP1-Blue™ Co-Culture Model.

  • 2024-06-21
  • Microorganisms 12(7)
  • • Philip A Sapp
    • Jeremy R Townsend
    • Trevor O Kirby
    • Marlies Govaert
    • Cindy Duysburgh
    • Lynn Verstrepen
    • Massimo Marzorati
    • Tess M Marshall
    • Ralph Esposito

  • PubMed: 39065031
  • DOI: 10.3390/microorganisms12071263

  1 Insight on

  • Improved Gut Barrier Function

  • Low evidence

  TEER was higher for AG1 ... vs. control ... following activated THP1-induced damage ... AG1 maintained TEER similar to the level of the negative control ... These in vitro data suggest that acute supplementation with AG1 might stimulate protective effects on GI permeability.

  Effect

  Beneficial

  Effect size

  Small

  Significant

  Yes