Bifidobacterium bifidum VPro 51 and Alleviated Non-Alcoholic Fatty Liver Disease

• Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis

  • 2021-12-31
  • Clinical Trial
  • Biomedicines 10(1)
  • • Linlin Wang
    • Ting Jiao
    • Q. Yu
    • Jialiang Wang
    • Luyao Wang
    • G. Wang
    • Hao Zhang
    • Jianxin Zhao
    • Wei Chen

  • PubMed: 35052765
  • DOI: 10.3390/biomedicines10010084

  10 Insights on

  • Alleviated Non-Alcoholic Fatty Liver Disease

  • Low evidence
  • Rigorous Journal
  • Animal Study

  The results showed that Bifidobacterium exerts species-specific effects on NAFLD. B. bifidum exerted these effects mainly through regulating the intestinal microbiota, increasing the relative abundance of Faecalibaculum and Lactobacillus, decreasing the relative abundance of Tyzzerella, Escherichia-Shigella, Intestinimonas, Osillibacter and Ruminiclostridium, and further increasing the contents of propionic acid and butyric acid, regulating lipid metabolism and intestinal permeability, and ultimately inhibiting liver inflammation and fat accumulation to alleviate NAFLD.

  Effect

  Beneficial

  Effect size

  Large